How to Get Potent Medicine in Persona 3 Reload, Potent Medicine in Persona 3 Reload

Potent Medicine in Persona 3 Reload with this comprehensive guide. Learn the essential steps, including the activation of Request 20 and navigating specific locations within Gekkoukan High School.

by R Vigneshwaraa

Updated Feb 08, 2024

How to Get Potent Medicine in Persona 3 Reload, Potent Medicine in Persona 3 Reload
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Potent Medicine in Persona 3 Reload

Potent Medicine holds a crucial role in Persona 3 Reload as it becomes a focal point in one of Elizabeth's requests. Request 20, available from the beginning of June 13, directs players to secure this unique Medicine, and its distinctiveness lies in the fact that it cannot be obtained through conventional means such as pharmacies or stores. Despite extensive efforts to scour various locations like Paulownia Mall, Iwatodai Strip Mall, and Port Island Station, coupled with interactions with numerous NPCs, the elusive Potent Medicine remains exclusive to a specific spot.

The quest for Potent Medicine unfolds as an intricate search, requiring precision in timing and location. Players must navigate through Gekkoukan High School, specifically the Nurse's Office on the first floor, following the activation of Request 20. Failing to adhere to the timing or attempting to secure the item before or after accepting the request may lead to a missed opportunity. The rarity of Potent Medicine makes its acquisition a unique challenge, emphasizing the importance of meticulous attention to Elizabeth's requests in the persona-filled journey of Persona 3 Reload.

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How to Get Potent Medicine in Persona 3 Reload?

Accept Request 20 from Elizabeth:

  • Ensure you have accepted Request 20 from Elizabeth before attempting to find Potent Medicine.

Navigate to Gekkoukan High School:

  • Head to Gekkoukan High School and locate the Nurse's Office on the first floor.

Proceed Down the West Corridor:

  • Move down the West corridor, passing the Faculty office, to reach the Nurse's Office.

Enter the Nurse's Office:

  • Pay attention to a line of text that appears before entering the Nurse's Office.

Engage in Dialogue with the Nurse:

  • Engage in a lengthy dialogue with the nurse, who will provide you with Potent Medicine.

Warning on Timing:

  • Be cautious not to enter the Nurse's Office before or after accepting the request, as it may result in wasting the day on a lecture that increases stats.

Prepare for Multiple Visits:

  • Acknowledge that this is part of a series of Elizabeth requests, requiring you to check various doors in Gekkoukan High School for specific items. Be prepared to return for subsequent requests.

Return to Elizabeth:

  • Once you have obtained Potent Medicine, return to Elizabeth.

Receive Steel Pipe Weapon:

  • As a reward for completing the request, Elizabeth will reward you with a Steel Pipe weapon.

Note on Timing of Completion:

  • Keep in mind that while the Steel Pipe is useful in the early game, completing the request later may impact its overall value. Be aware of the timing of your completion to maximize its effectiveness in your journey.

Persona 3

Persona 3 Reload is a video game where you play a character who goes back to their hometown ten years after their parents passed away. It's a remake of Persona 3 from 2006 and is part of the larger Megami Tensei series. You can play it on PlayStation 4, PlayStation 5, Windows, Xbox One, and Xbox Series X/S, and it was released on February 2, 2024.

Just like in the original game, the main character is a high school student with the ability to summon a Persona, a manifestation of their inner spirit. They join a group called the Specialized Extracurricular Execution Squad (S.E.E.S.) along with other Persona users. Together, their job is to defeat Shadows and solve the mystery of the Dark Hour.

Fans had been asking for a remake of Persona 3, especially after the success of Persona 5 in 2016, and Atlus officially acknowledged these requests. Reload's development started in 2019, and it was first reported in April 2023 before being officially announced in June 2023.

The game faithfully retells the story of the original Persona 3 but with updated graphics and features to match the later games in the series. Shigenori Soejima supervised the new art direction by Tomohiro Kumagai and character designs by Azusa Shimada. Atsushi Kitajoh created new music and rearranged the original compositions, featuring new vocal tracks by Azumi Takahashi and Lotus Juice.

Persona 3 Gameplay 

Persona 3 is a game that mixes role-playing and simulation elements. In the game, you play as a high-school student dealing with daily life, going to school, and building relationships. But, during a mysterious time called the Dark Hour, you also fight evil beings called Shadows.

Your days are split into daytime and evening. Besides scripted events, you choose how to spend your time each day, affecting your character's attributes: Academics, Charm, and Courage. In the evening, you can visit Tartarus, the main dungeon, to build your party's experience and items. On full moon days, there are boss battles to advance the story.

The game's main feature is Personas, creatures linked to Tarot cards. Each Persona has strengths, weaknesses, and different abilities. While other characters have their own Persona, the protagonist can use multiple Personas in battles.

You can create new Personas by fusing existing ones. Social links are new to the series, representing bonds formed with characters, each related to a Tarot card. Spending time with them increases social link ranks, giving bonuses when creating Personas of that Tarot card. Negative actions can break or reverse social links.

Tartarus is the main dungeon, visited in the evening. Players explore, split up party members, and battle Shadows. Boss floors and story progression impact progress. Spending too much time in Tartarus can make characters Tired or Sick, affecting performance. Battles start when you touch a Shadow, using a turn-based system with physical and elemental attacks. Exploiting weaknesses lets characters knock down enemies, gaining extra turns. Winning battles earns experience points, leveling up Personas for better stats and abilities.

Persona 3 System Requirements 

MINIMUM:

  • OS: Windows 10 (64-bit)
  • Processor: Intel Core i5-2300, AMD FX-4350
  • Memory: 8 GB RAM
  • Graphics: NVIDIA GeForce GTX 650 Ti, 2 GB; AMD Radeon HD 7850, 2 GB
  • DirectX: Version 12
  • Storage: 30 GB available space
  • Additional Notes: Performance Target: 720p, low graphics settings, @ 30 FPS

RECOMMENDED:

  • OS: Windows 10 (64-bit)
  • Processor: Intel Core i7-4790, AMD Ryzen 5 1400
  • Memory: 8 GB RAM
  • Graphics: NVIDIA GeForce GTX 1650, 4 GB; AMD Radeon R9 290X, 4 GB
  • DirectX: Version 12
  • Storage: 30 GB available space
  • Additional Notes: Performance Target: 1080p, high graphics settings, @ 60 FPS.

Persona 3 Trailer

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How to Get Potent Medicine in Persona 3 Reload- FAQs

1.  When does Request 20 for Potent Medicine become available in Persona 3 Reload?

 Request 20 becomes available at the beginning of June 13 in Persona 3 Reload.

2. What makes Potent Medicine unique in Persona 3 Reload?

Potent Medicine is distinctive as it cannot be obtained through conventional means such as pharmacies or stores in the game.

3.  Where is the elusive Potent Medicine located in Gekkoukan High School?

Potent Medicine is specifically found in the Nurse's Office on the first floor of Gekkoukan High School.

4. What happens if you attempt to secure Potent Medicine before or after accepting Request 20?

Failing to adhere to the timing of Request 20 or attempting to secure Potent Medicine before or after accepting the request may result in a missed opportunity.

5. Why is acquiring Potent Medicine considered a unique challenge in Persona 3 Reload?

The rarity of Potent Medicine, coupled with its exclusive location, adds a unique challenge to its acquisition, emphasizing the importance of careful attention to Elizabeth's requests in the game.